microcrystalline cellulose msds fmc

MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. BIOACCUMULATIVE POTENTIAL PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. Heavy metals, % NMT 0.001 Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Page 1 of 8. PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . The typical mean particle size is 20200 m. Document(s): certificate data msds. iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL Watch Now. Fiber supplements can lessen the absorption of some . Material safety data sheet - FMC Corporation. : 9004-34-6 Date Approved: 01/31/2008 . Avicel PH-101. Avicel RC-591 & CL-611 - Description. They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. ( We are artists at heart and creators by nature. gac74 [#B6`Wnw7 CAS #: 9004-34-6 . CAS #: 9004-34-6 It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. %PDF-1.5 However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. It is a white, free-flowing powder. CAS 9004-34-6. Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). pH 6.0 to 8.0 . Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. Have an order or account question, find answers in our Online Support articles. JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.) Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. MSDS Ref. Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. Remove Molecular weight: Not Applicable 1.5. It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. The cellulose molecule is formed through repeated condensation of cellobiose units. Earth Supplied Products LLC. >> 4 0 obj 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . Combines good flow and high compactibility. There have always been two different points of view for the liquidity of MCC. >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . All Rights Reserved. HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. stream zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? Molecular Weight null. These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. 0.25 - 0.37. It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. CAS 9004-34-6, pH 5 - 7.5. The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. /Type/Page This extends the funcionality of microcrystalline cellulose to meet specific viscosity, gelling, suspension and stabilizing properties ChemPoint is an approved supplier of LATTICE MCC in industrial applications, providing dedicated marketing, sales, order fulfillment, and technical support for customers in the EMEA region, Protect and improve AI potency, entrap oil droplets and improve stability, physical barrier that helps suspend particles and breaks down under shear and reforms quickly under rest. xv}O2' H~KEe9>G/,:9\i 9,LL!z Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . Avicel Microcrystalline Cellulose Physical Properties. Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. 102331. Synergies to simplify formulation challenges and reduce operational costs. An agricultural sciences company. The table below shows the most common physicochemical parameters of this raw material. : CL-611NF Date Approved: 01/13/2010. . stream 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. Medium size standard MCC grade, suited for the majority of directly compressible actives. GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. stream When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. <> CAS #: 9004-34-6 1.6. High performance lubricant that brings more to the tablet. J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . The most. undefined. By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. Wu, K. Zuurman, H.W. Product and Company Identification . AVICEL RC 581. Unique functionality for a broad range of pharmaceutical applications. (&E. >> As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. *r_ *?~4$ &0Y# This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication. Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. This Microcrystalline Cellulose . Avicel PC 611 Microcrystalline Cellulose. Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. 1. !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? MCC helps in the formation of spheres because of its . %PDF-1.3 cas:9000-11-7 msds Carboxymethyl cellulose. Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. PDF (4.11 mb) Footer menu 1. SDS - Safety Data Sheet. Learn about FMC's industry leading goal of net-zero emissions by 2035. endobj Microcrystalline Cellulose / Avicel PH-102. Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * /Resources 2 0 R Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. The data shown below apply only to Avicel PH 101. The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. 1.3. TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. Hi, let us know if you have any questions as you visit our website. They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose. Doses up to 30 g per day appear to be . Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). 130. bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O Buy Chemicals. Aqueous suspensions of microcrystalline cellulose have . We respect your privacy FMC Privacy Policy. B;vLZpHU%ChUyD+[ Gloves, eye protection and a dust mask should be used. Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. Avicel PC 611 (FMC Biopolymer) Supplied by. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. In 1964 FMC, Corporation . Origin(s): Plant/Botanical. Superior Performance: Provides excellent water uptake and rapid swelling . Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W Are you looking for information about products and services by region? EMCOCEL XLM 90. Safety Data Sheet for Cellulose microcrystalline 102331. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. 1 0 obj l~5C <> !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b Instead, they obtained a stable colloidal suspension. All rights reserved. Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& EINECS #: 232-674-9 1.7. FMC, JRS and Mingtai were estimated to hold for . JFIF ` ` ZExif MM * J Q Q Q C P}MFbN#[>r(y )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. Packaging: 34 x 50 kgs fiber drums. Catalog Number 102331. /MediaBox [0 0 612 792] stream No. <> < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. endobj Chemical Formula: (C6H10O5)n 1.4. Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. G2W4de=u183KGH{ vQ#4:1\wc << All Rights Reserved. 1 0 obj FMC Corporation. if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. No. A., and Smith, P. A. . Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. } !1AQa"q2#BR$3br JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. "l%I-*j|-)@ EtG[TQd%8,.fg4QqH'-dV ?3Z#GK# dGnF7x*3yY\VUwPhmyYT@f67Zcsmdi!%94K@:L# vJeU-kzRT-(YX/fKC 2008-2023 ChemPoint. It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. . DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) By producing Avicel . Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . Apply today! endobj Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. % MATERIAL SAFETY DATA SHEET Version: 1.0 1. The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the .

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